Websites - links

July 13, 2009

Cleveland Clinic launches its own WebMD

Cleveland Clinic last week unveiled Clevelandclinichealth.com, the hospital’s health-and-wellness portal and the latest in a string of online creations in the past year.

More health-care institutions have tried to turn their medical knowledge outward as they witness the success of social media and sites like WedMD. A site like MayoClinic.com is the standard bearer for the concept. And for nearly 15 years Case Western Reserve University, the University of Cincinnati and Ohio State University have developed the health-care question-and-answer site NetWellness.

The Clinic’s site, which redirects readers to a section of ClevelandClinic.org, culls the information from many of its print and other online publications, draws from a video database, includes an alphabetic index of health problems and intersperses personal stories about diseases.

Read the rest at MedCity News.

June 10, 2009

Introducing PathXchange

Since first hearing and seeing this site in the BioImagene booth at USCAP have uploaded over 50 cases and the service provided for scanning and web hosting your cases has been top notch! 

Included in the cases I have had scanned to date is a soft tissue tumor study set with comments submitted on a few of the cases (I still need to respond to...) about the diagnosis, histogenesis or prognosis of the lesions. 

We also recently uploaded another set of 40 pancreas cases with 10 examples each of 3 different forms of pancreatitis and 10 cases of carcinoma for comparison.  One of the goals of this project is to include gastroenterologists to share in the discussion as well.  Another application I plan on using the site for is resident education as "unknown" cases.

Overall, a great service and site and another example of the Pathology 2.0 revolution - content by users, for users, sharing cases, knowledge, experience & collective experience.

To date, over 800 users have joined and 1200 cases have been uploaded to the site.  I encourage you to take a look for yourself.

Introducing PathXchange – bringing pathologists together online

PathXchange.org (Px) is professional networking portal for the global pathology community.  Think of it as YouTube and Facebook for pathology! Px brings the field of pathology into the digital age with Web 2.0 features:

·       Browse interesting cases from around the world

·       Create your own online case gallery

·       Share your cases and slides with colleagues

·       Search our expanding global knowledge base

·       Learn about the latest advances in the field

·       Ask experts for their opinion on your case

Creating and sharing a case in Px takes only a minute. In just a few clicks, you can upload case images that you captured using any device, in any format, whether they are area snapshots or whole slide images. If you have glass slides for your case – no problem! Just mail us your slides.  We will digitize and upload the images for you.

Join the fastest growing pathology community! Sign up now for a FREE membership:
www.PathXchange.org.

Sign up before June 11, 2009 for a chance to win an iPod Shuffle. Create and share a case before June 18, 2009 for a chance to win an iPod Touch.

About PathXchange.org
Px is not-for-profit and vendor neutral.  BioImagene Inc. is a proud Platinum Sponsor of the site.  If you have any questions or would like to learn more about Px, don’t hesitate to send us an email or call us at (408) 207.4272. You can also find more information about Px by visiting our site:
www.PathXchange.org

May 29, 2009

Bruker and Carl Zeiss Announce Collaboration to Advance Molecular Histology

Integration of MIRAX Virtual Slide Scanner from Carl Zeiss into Bruker’s MALDI Molecular Imager™ Enables Non-Targeted Molecular Histology -- Combined Solution to be Introduced at German Pathology Society (DGP) Meeting in June 2009

BREMEN, Germany & JENA, Germany--(BUSINESS WIRE)--Bruker Daltonik GmbH and Carl Zeiss MicroImaging GmbH today announced the integration of the MIRAX Virtual Slide Scanner from Carl Zeiss into Bruker’s MALDI Molecular Imager. The goal of the Bruker–Carl Zeiss collaboration is to advance molecular histology research by providing an integrated solution (for research use only) for biological tissue research and pathology that adds non-targeted molecular information and ‘molecular contrast’ to histology.

The MALDI Molecular Imager is a molecular imaging system based on matrix-assisted laser desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry directly from tissue sections. It allows histology researchers to measure spatially resolved peptide, protein and lipid profiles in tissue sections. MALDI imaging is a non-targeted, broadly applicable molecular imaging approach without the need for any antibody or nucleotide probe. Tissue-type specific molecular signatures (e.g. from tumors) can be generated and used for biomarker discovery and molecular histology.

A major bottleneck in the interpretation of MALDI imaging data in pathology research has been the interpretation of results in a histological context. Until now, this has required repeated switching between evaluated MALDI molecular images and microscope views. The integration of Carl Zeiss’ MIRAX Slide Scanner results into the MALDI Molecular Imager solution allows the direct overlay of the full microscopic image with the full molecular and spectral information in one convenient visualization software tool, enabling true untargeted molecular histology.

Dr. Sören-Oliver Deininger, MALDI Imaging Product Specialist at Bruker Daltonics, explained: “Bruker has been the market and commercial technology leader in MALDI imaging for several years. Proprietary technologies such as the smartbeam™ laser for best spectra quality at highest speed and best spatial resolution, as well as the Bruker ImagePrep™ for easy and reproducible sample preparation, have turned MALDI imaging into a mainstream research application. Now, the full integration of the MIRAX virtual slides allows tissue and pathology researchers for the first time to evaluate their results directly in the histological context with the full spatial resolution of optical microscopy and the molecular information from MALDI imaging.

“This integrated molecular histology solution will significantly accelerate clinical pathology research, particularly in oncology, where the untargeted molecular information is expected to reveal additional subtle changes in tissue that cannot be distinguished by traditional histology methods today.”

“The integration of the MIRAX Virtual Slide Scanner into the MALDI Molecular Imager solution is a very good example of how the combination of two innovative technologies can create new benefits for biomedical research. With two technology leaders working together, we believe that we have a strong foundation for a novel, breakthrough histology solution. We look forward to working closely together with Bruker,” said Dr. Richard Ankerhold, business unit manager from Carl Zeiss.

Dr. Axel Walch, a pathologist at the Helmholtz Centre in Munich, and a user of both the MALDI Molecular Imager and the MIRAX slide scanner, commented: “The protein expression observed in MALDI Imaging data cannot be fully understood without the underlying histological information: the correlation of the MALDI image with a micrometer-resolution microscopic image is therefore mandatory for MALDI Imaging in clinical research. The Zeiss Mirax Scanner has the true advantage of online scalable high lateral resolution that can zoom in quickly to any tissue sections investigated by MALDI. Merging both techniques, Bruker MALDI Imaging and MIRAX virtual microscopy, leads to synergistic effects with outstanding benefits for clinical research. It truly completes the superior Bruker product line for imaging comprising of sample preparation, high performance MALDI mass spectrometry and highly sophisticated software for data interpretation.”

For further product information, please visit www.bdal.com/molecular-histology.

ABOUT BRUKER DALTONICS: For more information about Bruker Daltonics and Bruker Corporation (NASDAQ: BRKR), please visit www.bdal.com or www.bruker.com.

Photos/Multimedia Gallery Available: http://tinyurl.com/n82766

Source: Bruker Daltonik (press release)

May 06, 2009

Animated flu virus

I do not know what to make of all the recent news and stories about the Swine/North American/Newly mutated flu virus and how virulent it actually is. 

Nonetheless, The 1x Objective has some nice videos and other links on the proposed pathogenesis for the mutated strain.

May 05, 2009

Do you understand EIN and can you recognize it?

Pathologists are encouraged to check out the Endometrial Intraepithelial Neoplasia consensus exercise. Note the quiz closes on September 30.

Endometrial Intraepithelial Neoplasia (EIN) is the histopathologic presentation of premalignant endometrial disease. It is not just a renaming of an old diagnostic entity, “complex hyperplasia with atypia”, but is a refined set of diagnostic criteria based on epidemiologic and genetic data.

This consensus exercise is designed to both train users to recognize precancers and to test the robustness of the subjective criteria among a broad range of users.

If you are unfamiliar with EIN diagnostic terminology and criteria, read this review article (http://eva.unibas.ch/download/44825-reviewEIN.pdf) or peruse this website (http://www.endometrium.org/EIN%20Central/EINcentral.htm) before you begin.

You will be provided with a link to the answers and a discussion when you complete the quiz, and may return to this page to see how you scored relative to other participants when the quiz closes on September 30.

http://flexiform2.unibas.ch/formular.cfm?EID=1760

EIN Fact Sheet

May 01, 2009

Share and view pathology images at pathologypics.com

Came across a great site for pathology images at pathologypics.com.  Beyond viewing images, visitors to the site can contribute images and questions about particular cases.  According to the site, the intended use is as a "teaching tool for medical student and residents, providing a user driven web resource where you can post, browse and download images of interesting histology.  Images are grouped in user designated folders, and are tagged with key words to make finding relevant pictures easy."  With some help from Michael Datto and Kenneth Youens, the creators of the site, a few recent examples are provided below.

Very user-friendly upload and way to approriately tag images with contibutor noted in watermark.

liver infectious q fever granuloma 

adrenal adenoma and pheochomocytoma 

April 28, 2009

Web tracking of swine flu

Google maps, Twitter, RSS feeds, Web sites track spread of flu

April 27, 2009 | Bernie Monegain, Editor, Healthcare IT News

WASHINGTON – Technology of varying types is making it possible to track new cases of swine flu in close to real time.

The Centers for Disease Control and Prevention and the World Health Organization Web sites are posting up-to-the minute information about new cases and recommendations for the public and local and state officials on how to respond to the threat.

The CDC is tweeting updates at twitter.com/cdcemergency. The CDC and WHO are also providing data via an RSS feed, and the CDC is also offering podcasts.

In Mexico, reports indicate that more than 80 people may have died of the flu.

According to the most recent posting on the WHO's Web site Monday morning, the United States has reported 20 laboratory-confirmed human cases of swine influenza A/H1N1 (eight in New York, seven in California, two in Texas, two in Kansas and one in Ohio). All have had mild influenza-like illness, with only one requiring brief hospitalization. No deaths have been reported.

Google maps have pinpointed these cases as they are reported. Google announced last November it would employ its search engines to help the CDC track the flu.

Google queries, officials said, can be counted more quickly. They compared their aggregated queries against data provided by the CDC and found there is a close relationship between the frequency of the search queries and the number of people who are experiencing flu-like symptoms each week.
 
HealthMap aggregates news feeds from the WHO, Google News and elsewhere to map disease outbreaks around the world.  It also offers Twitter alerts on the latest swine flu news.

The CDC is working closely with officials in states where human cases of swine influenza A/H1N1 have been identified, as well as with health officials in Mexico, Canada and the WHO, according to a notice on the CDC Web site Monday. "This includes deploying staff domestically and internationally to provide guidance and technical support," the notice states. "CDC has activated its Emergency Operations Center to coordinate this investigation."

On Sunday, the Department of Health and Human Services declared a public health emergency in the United States. Officials called the measure "standard operating procedure that allowed them "to free up federal, state and local agencies and their resources for prevention and mitigation."

April 22, 2009

Pathology 2.0

This is an article I had an opportunity to write for ADVANCE for Administrators of the Laboratory in conjunction with a recent article entitled "Integrating Digital Pathology" in this month's issue.  My thanks to the publisher and Kelly Graham, assistant editor.

I will also present this topic at the upcoming CAP Futurescape meeting this June.

The term "Web 2.0" refers to a perceived second generation of Web development and design that aims to facilitate communication, secure information sharing, offer ability and collaboration on the Internet. Web 2.0 concepts have led to the development and evolution of Web-based communities, hosted services and applications, such as social-networking sites, video-sharing sites, wikis and blogs.  

The term was first used by Dale Dougherty and Craig Cline and became notable after the O'Reilly Media Web suggested a new version of the World Wide Web. It does not refer to an update to any technical specifications, but rather to changes in the way software developers and users utilize the Web.

According to time to Tim O'Reilly, "Web 2.0 is the business revolution in the computer industry caused by the move to the Internet as a platform, and in an attempt to understand the worlds for success on that new platform." Tim Berners-Lee, inventor of the Web, has questioned whether one can use the term in any meaningful way, since many of the technological components of Web 2.0 have existed since the early days of the Web.

Regardless of whether you view Web 2.0 as new or simply a modification of existing Internet technologies, Web 2.0 technologies allow users to do more than just retrieve information. The Web 2.0 tool/technologies allow content by users for users that is interactive and dynamic rather than static information being retrieved without input.

Changing Nature of Pathology

Because of the image-intense nature of anatomic pathology and traditional educational and clinical business practices (i.e., atlases, case sharing and consultation among colleagues), there is opportunity for incredible synergy between anatomic pathology and Web 2.0 technology vis-à-vis, Pathology 2.0.

The user-participatory nature of Web 2.0 allows for openness, freedom and collective intelligence. This expanded user experience, dynamic content and harnessing of collective intelligence in a simple fashion provide for the easy exchanged, sharing and delivery of all sorts of information with comment and discussion. Several examples of this currently exist, from image sharing sites on Flickr to Aperio's Second Slide consultation (www.secondslide.com) hosting service to BioImagene's PathXchange (www.pathxchange.org). Other examples that facilitate pathology image sharing include Med Pix (rad.usuhs.mil/medpix/) and Medting (www.medting.com). Sites such as MyPACS.net (www.mypacs.net) also allow for the creation of pathology teaching files in ways to data share and collaborate.

New Wave

Other technologies such as social media sites (Facebook and Youtube) also allow users to post and share collective intelligence for research, educational and clinical practice. Again, the ability for content by users for users in a simple and accessible format allow glass slides (more accurately, images derived from glass slides) to be shared and viewed in a way that extends beyond institutional walls takes advantage of Web 2.0.

My Digital Pathology Blog at www.tissuepathology.com serves to educate pathologists and the pathology community on the deliverables of digital pathology, current news and events and applications in education, research and clinical practice. This is a form of "academic blogging" that may be timely or relevant to interested audience participants. It also allows for collaboration between industry and practitioners to expand the community, enhance the discussion, promote the technology and offer opinion from my perspective while also allowing others to comment, criticize and share in an open and dynamic dialog. Blogging allows users to share content and ideas, gives others a sense of your own work and interests and in my case, as an academic pathologist, allows a platform for non-peer reviewed writing that is original and unedited content (for better or worse). This extends into other networking opportunities.

Certainly these are disruptive technologies that some may not be comfortable with or feel have a place in medicine or pathology. There is a level of transparency to which we all must grow accustomed that extends far beyond our own microscope and slide storage rooms. The real value is in the collective intelligence that can now be harnessed.

Web 2.0 is about the next generation of applications on the Internet, featuring user-generated content, collaboration and community and offers technology to expand our horizons and to showcase our specialty of anatomic pathology like never before.

April 06, 2009

From epathologies.com - What is the diagnosis?

Nice case with multiple fields and images at epathologies.com.

Make sure to check out the pdf presentation as well.

02x12m14x400m  

April 03, 2009

Interpath - Pathology on the iPhone

If you haven't seen this yet - Aperio blog has story on "Interpath - Pathology on the iPhone"

 


Interpath for iPhone from IMI on Vimeo.

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